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The shape of the resulting dimer will also presumably align imperfectly with EREs In either case, relatively few oestrogen-mimicking molecules actually trigger the cascade of oestrogenic effects which normally results from oestrogenic hormone exposure, and so the overall effect is muted Further information on the possible effects of oestrogens in the aquatic environment can be found in Stahlschmidt-Allner et al (1997) and useful reviews of the effects of pollutants on sh reproduction and reproductive behaviour can be found in Kime (1995) and Jones and Reynolds (1997) However, antioestrogenic environmental contaminants can act as weak antagonists at the ER, binding irreversibly with it but not producing dimers which can interact with the EREs They thus block the action of natural oestrogenic agonists, and the more receptors which are occupied, the weaker the action of the hormone will be.

However, it is important to note that some masculinising effects in the environment, eg TBT-induced imposex in molluscs, are caused most probably by an effect on hormone synthesis (aromatase inhibition) or excretion rather than by direct androgenic action (see below) Furthermore, the masculinising effects of the plant-derived substances (eg -sitosterol) in pulpmill ef uents appear to be due to a range of effects on the pituitary-gonadal axis, as well as some oestrogen receptor-mediated action and alterations in cholesterol availability (van der Kraak et al, 1998; Tremblay & van der Kraak, 1999) 5133 Immediate consequences The immediate consequences of sh exposure to environmental androgens and/or antiandrogens are not very well understood However, several studies have reported the masculinisation of female poeciliids (mosquito sh) from streams recipient of kraft mill ef uents (KME) (Howell et al, 1980; Bortone et al.

The capabilities of different devices are best expressed using an ontology, against which the pro les of those devices are validated W3C has a Device Independence activity, which works with CC/PP (Composite Capability/Preference Pro les) based on RDF [3] A CC/PP pro le contains CC/PP attribute names and associated values The pro le is structured to allow an entity to describe its capabilities by reference to a standard pro le, accessible to a peer entity, and a smaller set of features that are in addition to or different than the standard pro le A CC/PP vocabulary consists of a set of CC/PP attribute names, permissible values, and associated meanings CC/PP is compatible with IETF media feature sets (CONNEG) [39] in the sense that all media feature tags and values can be expressed in CC/PP.

An example of an oestrogen antagonist with therapeutic value is the drug tamoxifen which is used to treat or prevent breast cancer by blocking the potentiating effect of natural oestrogens Two different ER forms have been identi ed in mammals (Kuiper et al, 1996; Kuiper & Gustafsson, 1997), and possibly more forms occur in some sh species (Tchoudakova et al, 1999) A testicular ER has a higher af nity than the liver ER for oestrogens and xenoestrogens (Loomis & Thomas, 1999) Different tissues may therefore have different susceptibilities to chemical disruption There have been reports of some endocrine effects not mediated through ER binding and activation For example, -hexachlorocyclohexane ( -HCH) produced oestrogen-like responses (cell division and growth) at levels found in human breast cancer tissue (Steinmetz et al, 1996) Compounds, which do not bind ER (Coosen & van Velson, 1989; Steinmetz et al.

, 1989; Drysdale & Bortone, 1989; Davis & Bortone, 1992) The masculinisation features include the development of a modi ed anal n (gonopodium) on pregnant females The development of a gonopodium was concomitant with male mating behaviours, and a hermaphroditic condition (vitellogenic oocytes and cysts of spermatids and spermatozoa) The consequences of masculinisation for individual sh is not known, since masculinisation does not continue after removal from KME and masculinised females (at early stages) gave birth to non-masculinised viable offspring in the aquaria Presently, there is no information on the fate of masculinised poeciliid populations subjected to continued exposures to KME androgens (Davis & Bortone, 1992) Male-biased sex ratios of embryos from the viviparous eelpout (Zoarces viviparus) have been identi ed in sh living in the ef uent gradient from a large Swedish pulp mill (Fig 56).

, 1996), may promote DNA transcription and thus produce oestrogenic responses, by passing signals through a highway of hormone and non-hormone response elements that turn genes on (Steinmetz et al, 1996) For example, p,p -DDT, at or below levels found in human breast fat tissue, bypassed the oestrogen receptor and stimulated a complex mixture of cell signalling proteins (growth factor receptors) and processes that eventually led to cell division (Shen & Novak, 1997) Also, some super cially similar feminisation effects may be caused through antiandrogenic mechanisms whereby the masculinising action of testosterone or 11-ketotestosterone is blocked at the androgen receptor by androgen antagonists such as p,p -DDE (eg Kelce et al, 1995; see section 5131) These results suggest that the same chemical and/or its metabolites can in uence the endocrine system in more than one way.